Codeine (CAS 76-57-3): storage and disposal
Found as codeine phosphate tablets and linctus in pharmacies and clinics, and as a pure reference material in some university labs, codeine is a Class B controlled drug. Its schedule depends on strength: Schedule 2 as the pure drug and Schedule 5 in low strength preparations. It is classified as harmful if swallowed, and medicines may be less hazardous than pure material, but cannot be assumed safe. Working out exactly which form you hold decides how it is handled.
- CAS number
- 76-57-3
- Form
- Solid
- Storage class
- General
- Signal word
- Warning
- Usual EWC code
- 16 05 06*
Harmful or irritant
This chemical is a manual enquiry
This is a controlled drug. Controlled drugs have their own legal requirements for storage, witnessing and destruction, so they cannot be priced through a standard form.
UK Misuse of Drugs Regulations 2001: Class B: Schedule 2 as the pure drug, Schedule 5 in low strength preparations.
It cannot be priced through a form. Please do not open or move it. Call us or send an enquiry and we will talk through the safe next step, which is often a store assessment.
What to do this week
- Leave it where it is. If it looks old, crystalline or damaged, do not open or move it and keep people away from the shelf.
- Write down the label wording, the rough age and where it is stored, from a safe distance.
- Send us those details, and a photo if you can take one without touching it.
Safe storage in a school or lab
Brown glass linctus bottles and blister packed or loose phosphate tablets are what a pharmacy tends to find, whereas a university may hold a small bottle of pure base or a reference standard in a locked research store. The schedule follows the strength, so a bottle of pure material is held and recorded differently from a pack of low strength medicine. If you are unsure which rule fits your stock, keep it in the locked controlled drugs arrangement and ask your responsible pharmacist or research controlled drugs lead. Keep your records up to date. Expired packs should be marked and separated from current stock, as linctus and tablets are both easy to reach for by mistake.
How to tell it has deteriorated
Sticky linctus bottles are usually the first thing you see: a cap glued down by dried syrup, sugary crystals at the neck and runs down the label. Those are the signs of use and age, and they do not tell you anything about strength. Tablets give few visual signs, so blister damage, chipping or loose unlabelled tablets are the things to note. Pure codeine is normally colourless crystals or a white crystalline powder, and it can be affected by light, so any colour change is worth recording. Faded handwritten labels on old university reference stock often leave the salt unclear, and that needs saying. Expiry dates on medicines remain the useful guide, and a clouded linctus should be withdrawn.
How it must be disposed of
This does not go through our standard collection route. It is arranged by manual enquiry, and never goes down the drain or into general waste.
No general chemical collection takes it, and codeine is not quoted online, so the first step is a manual enquiry when you need outside help, with a store assessment possibly following. The responsible pharmacist or accountable officer decides on healthcare stock, and a university should go through its own controlled drugs lead. Destruction may need an authorised witness, depending on the circumstances, and the schedule of what you hold matters here. List each form separately: pure material, strength of tablets and linctus, and the number and size of bottles. Say if a bottle has lost its label. Do not tip linctus into a sink or drain, and do not move stock from its locked place before advice.
| EWC code, laboratory chemicals | 16 05 06* |
|---|---|
| Discarded organic chemical, not a laboratory pack | 16 05 08* |
| Human healthcare setting | 18 01 09 |
| Hazardous waste | Yes |
The code depends on where the waste came from and what it is mixed with. Use the waste code finder to see why.
Common quantities we collect
Usually held as: phosphate tablets, linctus.
Part-used bottles and full containers are both fine. Tell us the size and how many, and an estimate is enough for a first price.
Where it is commonly held
Hazard statements
- H302 Harmful if swallowed.
Precautionary statements
- P203 Obtain, read and follow all safety instructions before use.
- P260 Do not breathe dust, fume, gas, mist, vapours or spray.
- P261 Avoid breathing dust, fume, gas, mist, vapours or spray.
- P263 Avoid contact during pregnancy and while nursing.
- P264 Wash hands and exposed skin thoroughly after handling.
- P264+P265 Wash hands and exposed skin thoroughly after handling. Do not touch eyes.
- P270 Do not eat, drink or smoke when using this product.
- P271 Use only outdoors or in a well-ventilated area.
- P272 Contaminated work clothing should not be allowed out of the workplace.
- P280 Wear protective gloves, protective clothing, eye protection and face protection.
- P301+P317 IF SWALLOWED: Get medical help.
- P302+P352 IF ON SKIN: Wash with plenty of water.
- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P317 Get medical help.
- P318 If exposed or concerned, get medical advice.
- P319 Get medical help if you feel unwell.
- P321 Specific treatment (see supplemental first aid instruction on this label).
- P330 Rinse mouth.
- P333+P317 If skin irritation or rash occurs: Get medical help.
- P362+P364 Take off contaminated clothing. And wash it before reuse.
- P403+P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents and container in accordance with local, regional, national and international regulations.
Substance as classified, dilutions may differ.
Questions
Are low strength codeine tablets treated the same way as pure codeine?
Not in every respect. Codeine is Class B, with the pure drug in Schedule 2 and low strength preparations in Schedule 5, so the requirements differ. Your responsible pharmacist or controlled drugs lead will confirm how each item is held, recorded and finally disposed of. List them separately, so nothing is treated by assumption.
How do we deal with a sticky bottle of linctus whose cap has seized?
Leave it closed. Do not force the cap or try to dissolve the crust with water. Stand the bottle on a wipeable tray inside the locked store and record it as out of date. Mention the seized cap in your request, because it may be relevant to how it is handled.
Our university found an old bottle of pure codeine from a research project. Who takes responsibility?
Start with your institution's controlled drugs lead or safety office. Keep the bottle locked, and record what the label says and where it was found, even if the original project has ended. Pure material sits in Schedule 2, so a manual enquiry may help if nobody has clear ownership of it.
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