Isoflurane (CAS 26675-46-7): storage and disposal
Isoflurane is a volatile anaesthetic used in clinics and veterinary practice, held in bottles in the pharmacy, the prep room or beside the anaesthetic machine. It may cause drowsiness or dizziness and may damage organs through prolonged or repeated exposure, a risk to the people who work around it day after day. It is not flammable at normal use. Exhausted scavenging canisters are part of the same waste stream.
- CAS number
- 26675-46-7
- Form
- Liquid
- Storage class
- General
- Signal word
- Warning
- Usual EWC code
- 16 05 06*
Harmful or irritant
Serious health hazard
What to do this week
- Check the label is readable and write down the opened date if it is not already there.
- Check it is stored as general stock and apart from the items listed under "Do not store with".
- If you no longer need it, add it to your disposal list so it goes on the next collection.
Safe storage in a school or lab
The practical risk for isoflurane is repeated low-level exposure for staff rather than fire, so the stock should be kept sealed in a cool store, away from the anaesthetic machine where bottles are opened and filled. Keep bottles upright with their caps and keyed filler fittings secure, and make sure the label faces out. A general dry store is the usual class, but a veterinary practice should keep it in a cupboard that is not used for food, with a stock record. Keep spare scavenging canisters apart from used ones, and label the used ones clearly.
How to tell it has deteriorated
A vet nurse or pharmacy technician can see the faults at a glance: a low level in a part-used bottle, a cap or filler fitting that has loosened, and a label that has faded or been stained by drips. Isoflurane gives few visible changes of its own, so a bottle that looks normal may still be old, and the expiry date on the label counts. Used scavenging canisters feel heavier than new ones and may smell of the agent around the machine. Record any bottle that has been opened for a long time and any leaking fitting.
How it must be disposed of
By specialist collection only. It never goes down the drain or into general waste. It is normally packed in a non-regulated or low hazard laboratory pack with compatible chemicals.
Waste bottles and exhausted scavenging canisters should be declared on the collection request, and each should be listed separately with its size and condition. Neither should be vented, emptied into a sink, or put in clinical waste. They leave by specialist collection, in compatible groups. A veterinary practice can use 18 02 08, a human healthcare setting 18 01 09, and laboratory stock 16 05 06*, with a loose discarded organic chemical using 16 05 08*. Keep the bottles sealed until collection and say whether the canisters are sealed in a bag.
| EWC code, laboratory chemicals | 16 05 06* |
|---|---|
| Discarded organic chemical, not a laboratory pack | 16 05 08* |
| Human healthcare setting | 18 01 09 |
| Veterinary setting | 18 02 08 |
| Hazardous waste | Yes |
The code depends on where the waste came from and what it is mixed with. Use the waste code finder to see why.
Common quantities we collect
Usually held as: anaesthetic.
Part-used bottles and full containers are both fine. Tell us the size and how many, and an estimate is enough for a first price.
Where it is commonly held
Hazard statements
- H336 May cause drowsiness or dizziness.
- H373 May cause damage to organs through prolonged or repeated exposure.
Precautionary statements
- P260 Do not breathe dust, fume, gas, mist, vapours or spray.
- P261 Avoid breathing dust, fume, gas, mist, vapours or spray.
- P271 Use only outdoors or in a well-ventilated area.
- P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P319 Get medical help if you feel unwell.
- P403+P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents and container in accordance with local, regional, national and international regulations.
Substance as classified, dilutions may differ.
Questions
Do exhausted scavenging canisters need declaring?
Yes. Waste bottles and exhausted canisters should both be declared on the collection request, listed separately with their condition. Keep canisters sealed and do not open or empty them.
Is isoflurane a fire risk?
It is not flammable at normal use, so it does not need a flammables cabinet. The concern is organ damage on prolonged or repeated exposure and drowsiness, so keep bottles sealed and away from where the machine is filled.
Which code applies in a veterinary practice?
Our list gives 18 02 08 for isoflurane in a veterinary setting and 18 01 09 for a human healthcare setting. Laboratory holders use 16 05 06*. The collector will confirm it once the bottles and canisters are described.
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