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Chemical collection and stock control for UK schools, universities and hospitals

Oxycodone (CAS 76-42-6): storage and disposal

A strong opioid painkiller, oxycodone is stocked by pharmacies and clinics as tablets and injection. It is a Schedule 2, Class A controlled drug. The substance is classified as harmful if swallowed and may cause drowsiness or dizziness, a modest list next to some of its neighbours in the same cabinet. Tablets and injections may be less hazardous still, but cannot be assumed safe. The controlled status, not the classification, is what decides how it is handled.

CAS number
76-42-6
Form
Solid
Storage class
General
Signal word
Warning
Usual EWC code
16 05 06*
  • Harmful or irritant pictogramHarmful or irritant

This chemical is a manual enquiry

This is a controlled drug. Controlled drugs have their own legal requirements for storage, witnessing and destruction, so they cannot be priced through a standard form.

UK Misuse of Drugs Regulations 2001: Schedule 2, Class A.

It cannot be priced through a form. Please do not open or move it. Call us or send an enquiry and we will talk through the safe next step, which is often a store assessment.

What to do this week

  1. Leave it where it is. If it looks old, crystalline or damaged, do not open or move it and keep people away from the shelf.
  2. Write down the label wording, the rough age and where it is stored, from a safe distance.
  3. Send us those details, and a photo if you can take one without touching it.

Safe storage in a school or lab

Harmful if swallowed would not on its own call for special storage, and that is the trap: the legal status decides, and oxycodone stays in the existing locked controlled drugs arrangement with the register up to date. Expired strips and bottles should be kept in a marked section, physically apart from dispensing stock, because modified-release and immediate-release tablets are easily confused when loose. Injection ampoules should stay in their cartons. Patient returned tablets are usually the worst-documented stock in the cabinet, often with mixed strengths in a single bottle, and they should remain sealed and separated from your own holding. Keep a clean count of what is out of date, rather than leaving it to the next audit.

How to tell it has deteriorated

Tablets normally look uniform, with a coating and a colour matching the strength printed on the pack, and the injection should be clear and colourless. Oxycodone itself gives few visual signs of ageing, so the expiry date and the batch number count for more than appearance. Things that are not normal include chipped or crushed tablets, tablets of different colours in one bottle, cracked ampoules or blisters that are split or partly emptied. Those signs are more likely to point to handling problems or diversion than to chemical change, so report them to the person responsible for controlled drugs. Damp clumping in a loose bottle can also occur with returned stock. Faded labels and missing batch details need recording in the register.

How it must be disposed of

This does not go through our standard collection route. It is arranged by manual enquiry, and never goes down the drain or into general waste.

List strength, form, modified or immediate release, batch, expiry date and exact count against the register line, and separate your own stock from anything returned by patients. Oxycodone is not quoted online, and the online quote path does not take it. Where a holding is mixed or poorly documented, use a manual enquiry, and a store assessment can follow. The final decision belongs to the accountable officer or responsible pharmacist, and destroying stock needs an authorised witness in many cases, so this is not an ordinary item for a chemical collection. Tablets should never be flushed, and they should not be crushed or dissolved to empty a bottle. Keep them locked up and unchanged until you have advice.

Waste codes and transport details for Oxycodone
EWC code, laboratory chemicals16 05 06*
Discarded organic chemical, not a laboratory pack16 05 08*
Human healthcare setting18 01 09
Hazardous wasteYes

The code depends on where the waste came from and what it is mixed with. Use the waste code finder to see why.

Common quantities we collect

Usually held as: tablets, injection.

Part-used bottles and full containers are both fine. Tell us the size and how many, and an estimate is enough for a first price.

Where it is commonly held

Hazard statements

  • H302 Harmful if swallowed.
  • H336 May cause drowsiness or dizziness.
Precautionary statements
  • P203 Obtain, read and follow all safety instructions before use.
  • P260 Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261 Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263 Avoid contact during pregnancy and while nursing.
  • P264 Wash hands and exposed skin thoroughly after handling.
  • P270 Do not eat, drink or smoke when using this product.
  • P271 Use only outdoors or in a well-ventilated area.
  • P280 Wear protective gloves, protective clothing, eye protection and face protection.
  • P301+P317 IF SWALLOWED: Get medical help.
  • P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P318 If exposed or concerned, get medical advice.
  • P319 Get medical help if you feel unwell.
  • P330 Rinse mouth.
  • P403+P233 Store in a well-ventilated place. Keep container tightly closed.
  • P405 Store locked up.
  • P501 Dispose of contents and container in accordance with local, regional, national and international regulations.

Substance as classified, dilutions may differ.

Questions

Does oxycodone need the controlled drugs cabinet when its hazard list is so short?

Yes. The Misuse of Drugs Regulations 2001 set the storage and record requirements here, and the hazard statements do not change that. Keep tablets and injections in the existing locked arrangement, with the register up to date, even after they have expired or have been set aside for destruction.

How should we record a returned bottle with mixed tablets?

Record what you can see, without trying to sort or identify every tablet by handling them. Keep the bottle sealed and separated from working stock. Use your local process for returned controlled drugs and ask the responsible pharmacist to decide how it should be described and dealt with.

Do oxycodone tablets become unsafe when they pass the expiry date?

An expired tablet should be withdrawn from use, even if it looks unchanged, and it stays a controlled drug. The tablets show few visible signs of ageing, so a good appearance proves nothing. Mark them as out of date in the register and keep them locked until destruction has been arranged.

Guidance only. Check your own risk assessment and your supplier's safety data sheet.

Hazard data source: PubChem GHS Classification, retrieved 31 Oct 2026. Formula C18H21NO4. EC number 200-960-2.

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