Skip to content

Chemical collection and stock control for UK schools, universities and hospitals

Papain (CAS 9001-73-4): storage and disposal

Papain is a protein-digesting enzyme from papaya, held by schools, colleges and universities for practicals on proteins and gelatine and for sample preparation. It comes as a powder. The recorded hazards are skin and eye irritation, respiratory irritation and H334, the warning that inhaled dust can cause allergy or asthma symptoms, and the powder form is what makes the bottle awkward.

CAS number
9001-73-4
Form
Solid
Storage class
General
Signal word
Danger
Usual EWC code
16 05 06*
  • Harmful or irritant pictogramHarmful or irritant
  • Serious health hazard pictogramSerious health hazard

What to do this week

  1. Check the label is readable and write down the opened date if it is not already there.
  2. Check it is stored as general stock and apart from the items listed under "Do not store with".
  3. If you no longer need it, add it to your disposal list so it goes on the next collection.

Safe storage in a school or lab

The hazard that decides where papain goes is its dust. It is a respiratory sensitiser as well as an irritant, so keep it in a tightly closed bottle on a general shelf below eye level, with the label visible and a note of the opening date. A school or college may also hold meat tenderiser or food-grade papain bought for the kitchen or the canteen, and that must stay with food supplies, never in the prep room beside laboratory stock. Keep the powder away from damp areas by the prep room washing area, because it absorbs moisture and cakes. In a university lab, avoid sharing one spatula between bottles. Buy small, because a half-used bottle of fine sensitising powder is the stock that causes most trouble later.

How to tell it has deteriorated

A good papain bottle holds a loose, pale to buff powder. What looks normal for papain is a little fine dust in the neck. What does not is hard lumps, a darker caked patch, a smell that was not there before or a sticky film on the inside of the cap. Papain breaks down proteins, but damage to labels, gloves or card is not a reliable sign of deterioration. Record any powder residue, damaged labels or container defects. As with every enzyme its activity fades invisibly, so a bottle that no longer softens jelly or meat in a practical may look entirely normal. Do not blow or sweep dust from a cracked bottle.

How it must be disposed of

By specialist collection only. It never goes down the drain or into general waste. It is normally packed in a non-regulated or low hazard laboratory pack with compatible chemicals.

Specialist collection takes it away, with sealed bottles grouped alongside other compatible solids in a lab pack. The code that fits a laboratory item is 16 05 06*. Say plainly on the paperwork that it carries the inhalation sensitiser statement, because the people loading and unloading the packs will be exposed to the dust if a bottle breaks. Leftover powder should not be brushed into the bin, washed into a sink or drain, or collected in general waste. If the stock is food-grade kitchen papain and not a laboratory reagent, describe it as such and let the collector decide how it is classed.

Waste codes and transport details for Papain
EWC code, laboratory chemicals16 05 06*
Hazardous wasteYes

The code depends on where the waste came from and what it is mixed with. Use the waste code finder to see why.

Common quantities we collect

Usually held as: solid.

Part-used bottles and full containers are both fine. Tell us the size and how many, and an estimate is enough for a first price.

Where it is commonly held

Hazard statements

  • H315 Causes skin irritation.
  • H319 Causes serious eye irritation.
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H335 May cause respiratory irritation.

Substance as classified, dilutions may differ.

Questions

Can we use the same papain for the canteen and the lab?

Keep them apart. Food-grade tenderiser belongs with food supplies. Laboratory papain carries irritant and inhalation sensitiser statements and stays in the prep room. Once a bottle has been in the lab it should not go back to the kitchen.

What is H334 on the papain label?

It means the dust may cause allergy or asthma symptoms or breathing difficulties if inhaled. The fine powder is the problem, so keep bottles closed, avoid shaking them, and keep staff with asthma away from open stock.

An old papain bottle has caked and has no date. What now?

Leave it closed, note what the label says and arrange collection. A caked, undated bottle of sensitiser powder is not worth opening to check, and a described lab pack item is easier for the collector than a mystery.

Guidance only. Check your own risk assessment and your supplier's safety data sheet.

Hazard data source: GB mandatory classification list (HSE), retrieved 31 Oct 2026.

Request collection Add to register