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Chemical collection and stock control for UK schools, universities and hospitals

Silver sulfadiazine (CAS 22199-08-2): storage and disposal

Pharmacies and clinics hold silver sulfadiazine mainly as a 1% cream in tubes and tubs for wound care. The pure substance carries skin, eye and respiratory irritation classifications. The classification of a formulated 1% cream must be established from the information for that particular product. The silver content should be stated in the waste description, so expired or part-used containers are named accurately and not left as an unidentified return.

CAS number
22199-08-2
Form
Solid
Storage class
General
Signal word
Warning
Usual EWC code, laboratory stock
16 05 06*
  • Harmful or irritant pictogramHarmful or irritant

What to do this week

  1. Without moving anything that looks damaged, check the label is readable and write down the opened date if it is not already there.
  2. Check it is stored as general stock, and apart from anything listed under "Do not store with" on this page. If nothing is listed, that does not prove it is safe with everything.
  3. If you no longer need it, add it to your disposal list so it can be included in a collection.

Safe storage in a school or lab

In a pharmacy cupboard it sits with other topical preparations, but the practical point is that part-used tubs left open in a clinic treatment room are the usual problem. Keep unopened tubes in their outer boxes on a general shelf, away from heat and direct light, and keep opened tubs closed and labelled with the date opened. Name it on any returns or waste list, so the silver content is stated when the waste is classified. Nothing about it needs a corrosive or flammable store. A clinic that holds a stock list should record batch and expiry so that out-of-date tubes are found before they accumulate.

How to tell it has deteriorated

Silver compounds in creams are light-sensitive, and the product is well known for darkening with exposure, so a white cream that has turned grey, brown or dark in a tub or at the tube nozzle has been kept in the light or opened for a long time. Look for separation of the base, a hard crust at the tube neck and a cap that no longer closes. Dark staining on shelving or on the outer box is another sign. A tub with no legible expiry or batch is a problem of its own, because nobody can tell how old it is.

How it is disposed of

We arrange this by specialist collection. We do not publish a drain or general waste route for any chemical. It is normally packed in a general laboratory pack with compatible chemicals.

Record what is actually in the container before asking for a collection: tube or tub, approximate fill, expiry if readable, and whether it has been opened. The paperwork route depends on setting. For unwanted silver sulfadiazine medicinal cream from human healthcare, 18 01 09 is the usual code for medicines other than cytotoxic and cytostatic medicines. Separate laboratory stocks must be classified according to their actual composition and waste origin before selecting a code. Unwanted cream does not belong in the sink, sharps bin or ordinary bin, and nobody should try to squeeze it out or wipe it down a drain. Keep the item in its box or in a sealed bag, and request a specialist collection from the carrier.

Waste codes for Silver sulfadiazine
Usual EWC code, laboratory stock16 05 06*
Discarded organic chemical, not a laboratory pack16 05 08*
Human healthcare setting18 01 09
Usually classed as hazardous wasteYes

The code depends on where the waste came from and what it contains, and classifying it is the producer's duty. Use the waste code finder to see why.

Common quantities

Usually held as: 1% cream.

Tell us the container size and how many you hold. An estimate is enough to start with, and some items cannot be priced until someone has looked at them.

Where it is commonly held

Hazard statements

  • H315 Causes skin irritation.
  • H319 Causes serious eye irritation.
  • H335 May cause respiratory irritation.
Precautionary statements
  • P261 Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264 Wash hands and exposed skin thoroughly after handling.
  • P264+P265 Wash hands and exposed skin thoroughly after handling. Do not touch eyes.
  • P271 Use only outdoors or in a well-ventilated area.
  • P280 Wear protective gloves, protective clothing, eye protection and face protection.
  • P302+P352 IF ON SKIN: Wash with plenty of water.
  • P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319 Get medical help if you feel unwell.
  • P321 Specific treatment (see supplemental first aid instruction on this label).
  • P332+P317 If skin irritation occurs: Get medical help.
  • P337+P317 If eye irritation persists: Get medical help.
  • P362+P364 Take off contaminated clothing. And wash it before reuse.
  • P403+P233 Store in a well-ventilated place. Keep container tightly closed.
  • P405 Store locked up.
  • P501 Dispose of contents and container in accordance with local, regional, national and international regulations.

Substance as classified, dilutions may differ.

Questions

Can expired silver sulfadiazine cream go in the normal pharmacy returns?

Not without checking. Silver sulfadiazine cream must be described accurately and its correct medicinal waste classification established. Request a specialist collection rather than mixing it into an unidentified return.

Why has the cream in the tub turned dark?

Silver compounds darken with light and time. A dark cream has been exposed or kept open for a long while. Record the change, keep the lid on and arrange collection.

Which waste code applies in a hospital pharmacy?

A human healthcare setting usually uses 18 01 09 for this item, though the producer classifies the waste. A laboratory pack uses 16 05 06*, and discarded organic chemical outside a pack uses 16 05 08*. Say which setting you are in.

Do part-used tubes need to be recorded?

Yes. Note whether each is opened, approximately how full it is, and the expiry date if legible. That lets the collection be described accurately and stops tubes drifting into general clinical waste.

Guidance only. Check your own risk assessment and your supplier's safety data sheet.

Hazard data source: PubChem GHS Classification, retrieved 31 Oct 2026. Formula C10H9AgN4O2S. EC number 244-834-5.

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