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Chemical collection and stock control for UK schools, universities and hospitals

Tris hydrochloride (CAS 1185-53-1): storage and disposal

University research stores and pathology laboratories hold Tris hydrochloride as a white solid used to make buffers. It is not normally classified as hazardous, yet it remains a chemical waste that needs an accurate description. The hydrochloride is a different substance from Tris base, and stock lists that blur the two lead to wrong descriptions when it is time for collection.

CAS number
1185-53-1
Form
Solid
Storage class
General
Usual EWC code, laboratory stock
16 05 09

What to do this week

  1. Without moving anything that looks damaged, check the label is readable and write down the opened date if it is not already there.
  2. Check it is stored as general stock, and apart from anything listed under "Do not store with" on this page. If nothing is listed, that does not prove it is safe with everything.
  3. If you no longer need it, add it to your disposal list so it can be included in a collection.

Safe storage in a school or lab

Keep it separate from strong alkalis and from hypochlorite bleach. The first is because an alkali changes what the salt is, and the second is because hypochlorite reacts with amine salts to form irritating, toxic chloramines. Otherwise it belongs on the general shelf in a dry, labelled and well organised store, dated on arrival and apart from food grade supplies. Keep the tub tightly closed, since the solid may take up moisture from the air and set. Store it away from the tub of Tris base so the two cannot be confused. A shared university stockroom often has both on adjacent shelves, which is where mislabelled decants begin.

How to tell it has deteriorated

A tub in good order holds white, loose crystals or powder. Clumping, a damp surface or a solid cake at the bottom means moisture has got in, usually through a cap that does not seat properly. Beyond that the substance gives few visible signs, so a normal look is no guide to age. The label is the weak point: the name Tris appears on several different containers, and without the word hydrochloride on the label a tub can be misfiled. General checks also apply, including crusting at the neck, a cracked tub and an unknown date of receipt. Unidentified or undated tubs should be recorded and held for collection.

How it is disposed of

We arrange this by specialist collection. We do not publish a drain or general waste route for any chemical. It is normally packed in a non-regulated or low hazard laboratory pack with compatible chemicals.

Waste code 16 05 09 is the usual entry for this item as non hazardous stock, and a human healthcare setting would usually use 18 01 07 instead, and the producer confirms the classification. That does not make it ordinary rubbish: it must not go into a sink, a drain, a general waste bin or a skip, and nobody should try to treat it first. A waste transfer note accompanies it, and the description must be accurate under the Duty of Care. Specialist collection takes it, with the tub grouped alongside compatible items. State on the record that it is the hydrochloride salt, not Tris base, along with the container size.

Waste codes for Tris hydrochloride
Usual EWC code, laboratory stock16 05 09
Human healthcare setting18 01 07
Usually classed as hazardous wasteNo

The code depends on where the waste came from and what it contains, and classifying it is the producer's duty. Use the waste code finder to see why.

Common quantities

Usually held as: solid.

Tell us the container size and how many you hold. An estimate is enough to start with, and some items cannot be priced until someone has looked at them.

Where it is commonly held

Questions

Is Tris hydrochloride the same waste as Tris base?

No. They are separate entries and are described differently. Tris hydrochloride is not normally classified, while Tris base is classified as irritating. Name the salt precisely on the collection record.

Does non hazardous mean it can go in the bin?

No. It remains a chemical waste and must be described accurately. It does not go into a sink, drain, general waste bin or skip. Collection is by specialist route, with a waste transfer note.

Why has our tub set solid?

The solid may have taken up moisture because the cap was not closed fully. Do not chip at it or try to dry it out. Record the tub, keep it closed and include it in the next collection.

Guidance only. Check your own risk assessment and your supplier's safety data sheet.

Hazard data source: PubChem GHS Classification, retrieved 31 Oct 2026. Formula C4H12ClNO3. EC number 214-684-5.

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