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Chemical collection and stock control for UK schools, universities and hospitals

Methyl isobutyl ketone (CAS 108-10-1): storage and disposal

Methyl isobutyl ketone, known in many labs as MIBK, is a highly flammable solvent with a sweetish, camphor-like smell. School, college and university stores hold it as neat liquid, mostly for extractions and analytical methods. It is harmful if inhaled and suspected of causing cancer. Few people expect a ketone on a peroxide former list, yet it appears on class B lists, so the opening date matters more than its plain appearance suggests.

CAS number
108-10-1
Form
Liquid
Storage class
Flammable
Signal word
Danger
Usual EWC code, laboratory stock
16 05 06*
  • Flammable pictogramFlammable
  • Harmful or irritant pictogramHarmful or irritant
  • Serious health hazard pictogramSerious health hazard

What to do this week

  1. Leave it where it is. If it looks old, crystalline or damaged, do not open or move it and keep people away from the shelf. If there is immediate danger, such as a leak, fumes or a fire, leave the area and call 999.
  2. Write down the label wording, the rough age and where it is stored, from a safe distance.
  3. Send us those details, and a photo if you can take one without touching it.

Safe storage in a school or lab

Highly flammable vapour puts it in a ventilated fire-resistant cabinet with spill containment, away from ignition sources, oxidisers, oxidising acids and corrosive stock. Technicians often shelve it with acetone and treat it the same way, but acetone carries no such date concern, so give this bottle its own label marks: received, opened, and a review 12 months after opening. As a ketone solvent, it softens some plastics and rubbers over time, so look at cap liners when you check the date. Vapour can cause drowsiness or dizziness and irritate the airways, so a leaking bottle in a small prep room is a problem well before fire becomes one. Use only a spark-free refrigerator if any cold storage is needed.

How to tell it has deteriorated

Normal stock is clear and colourless, with little to show from one year to the next. That is the difficulty: it gives few visual signs while ageing, and a bottle can look perfect with an unknown opening date. A lower level than recorded, a softened or sticky cap liner, and a faded label are what you can actually observe. Yellowing or thickening would suggest age or contamination, and crystals around the cap would be a serious warning. If an opened bottle is old, undated or shows any of these, do not move it, do not open it, and get a specialist assessment. Date checks carry more weight than any look at the liquid, and peroxide testing is for competent staff only.

This can form peroxides as it ages, especially after opening. Age and the opened date matter more than appearance, so a container with no opened date should be treated as old.

Review after 12 months: Review interval after opening from the cited peroxide former lists, not an expiry date from a manufacturer. Class C and all other chemicals are left null.

How it is disposed of

We arrange this by specialist collection. We do not publish a drain or general waste route for any chemical. It is normally packed in a flammable laboratory pack with compatible chemicals.

Packing puts it among compatible non-halogenated flammable solvents, which is simple as long as it is listed under its proper name and not lumped in as "old ketone" or simply "solvent". Abbreviations on hand-written labels cause trouble, so copy down the full name where possible. Separate any opened and undated bottle on your list, as those need assessing before they can be grouped with the rest. Extraction residues hold whatever was extracted, so they are a different waste from neat stock. It must never go into a sink or drain, a general waste bin or a skip, and nobody should try to treat it first. Specialist collection is the route, and school stock usually falls under code 16 05 06*.

Waste codes for Methyl isobutyl ketone
Usual EWC code, laboratory stock16 05 06*
Discarded organic chemical, not a laboratory pack16 05 08*
Usually classed as hazardous wasteYes

20 01 13* (solvents) belongs to municipal collections and is shown for reference only. It is not the normal code for a laboratory collection.

The code depends on where the waste came from and what it contains, and classifying it is the producer's duty. Use the waste code finder to see why.

Do not store with

  • OxidiserOxidisers can ignite flammable materials or make a fire far more intense.
  • AcidSome acids, especially oxidising acids, can ignite flammable materials, and acid fumes attack containers and seals.
  • CorrosiveA leak of corrosive stock can break down flammable containers and feed a fire.

Named chemicals to keep apart

  • Acetic acidOxidising acids can ignite flammable materials, and acid fumes attack containers and seals.
  • Calcium hypochloriteOxidisers can ignite flammable materials or make a fire far more intense.
  • Hydrochloric acidOxidising acids can ignite flammable materials, and acid fumes attack containers and seals.
  • Hydrogen peroxideOxidisers can ignite flammable materials or make a fire far more intense.
  • Nitric acidOxidising acids can ignite flammable materials, and acid fumes attack containers and seals.
  • Potassium nitrateOxidisers can ignite flammable materials or make a fire far more intense.
  • Potassium permanganateOxidisers can ignite flammable materials or make a fire far more intense.
  • Sulfuric acidOxidising acids can ignite flammable materials, and acid fumes attack containers and seals.
Show 2 more
  • Thionyl chlorideA leak of corrosive stock can break down flammable containers and feed a fire.
  • Zinc chlorideA leak of corrosive stock can break down flammable containers and feed a fire.

Common quantities

Usually held as: neat.

Tell us the container size and how many you hold. An estimate is enough to start with, and some items cannot be priced until someone has looked at them.

Where it is commonly held

Hazard statements

  • H225 Highly flammable liquid and vapour.
  • H319 Causes serious eye irritation.
  • H332 Harmful if inhaled.
  • H335 May cause respiratory irritation.
  • H336 May cause drowsiness or dizziness.
  • H351 Suspected of causing cancer.
  • EUH066 Repeated exposure may cause skin dryness or cracking.
Precautionary statements
  • P203 Obtain, read and follow all safety instructions before use.
  • P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P233 Keep container tightly closed.
  • P240 Ground and bond container and receiving equipment.
  • P241 Use explosion-proof electrical, ventilating and lighting equipment.
  • P242 Use non-sparking tools.
  • P243 Take action to prevent static discharges.
  • P261 Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264+P265 Wash hands and exposed skin thoroughly after handling. Do not touch eyes.
  • P271 Use only outdoors or in a well-ventilated area.
  • P280 Wear protective gloves, protective clothing, eye protection and face protection.
  • P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower.
  • P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317 Get medical help.
  • P318 If exposed or concerned, get medical advice.
  • P319 Get medical help if you feel unwell.
  • P337+P317 If eye irritation persists: Get medical help.
  • P370+P378 In case of fire: Use suitable extinguishing media to extinguish.
  • P403+P233 Store in a well-ventilated place. Keep container tightly closed.
  • P403+P235 Store in a well-ventilated place. Keep cool.
  • P405 Store locked up.
  • P501 Dispose of contents and container in accordance with local, regional, national and international regulations.

Substance as classified, dilutions may differ.

Questions

Why is a ketone on a peroxide former list when acetone is not?

Published class B lists include methyl isobutyl ketone because of how its structure behaves in air over time, which differs from acetone. In practice, it means opened bottles carry a date and are reviewed at 12 months, and any peroxide testing stays with competent staff.

Can old MIBK be added to the general non-halogenated solvent waste?

Not if the bottle is old, undated or suspect, as it should stay closed for assessment. In-date surplus should still be listed on its own, by name. Adding it to a mixed bottle hides what is in there and makes accurate description harder for everyone.

Our opened bottle has no date. Is there any way to estimate its age?

Stock records, order history or a supplier batch label may help, and you can check all of them without touching the bottle much. If none settles it, count the bottle as undated. That means leaving it closed where it stands and asking for a specialist assessment.

Guidance only. Check your own risk assessment and your supplier's safety data sheet.

Hazard data source: PubChem GHS Classification, retrieved 31 Oct 2026. Formula C6H12O. EC number 203-550-1.

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